Biotechnology and technology company developing integrated systems for making biology computational, scalable, and operational in the real world. Its work brings together biological samples, sequencing, multimodal data, software, AI, and laboratory infrastructure within a unified technological framework.
At the core of HoX is the concept of the “Biology Computer”: an integrated system designed to automate biological operations and connect fragmented scientific data into a machine-readable, actionable substrate. Its platform combines sequencing services, bioinformatics, data infrastructure, and specialized applications, enabling biological information to be explored, analyzed, and shared without the conventional separation between laboratory workflows and computational systems.
The company develops technologies across several fields, including genomics, single-cell analysis, precision medicine, and biosecurity. Its systems are designed to operate from individual laboratories to large-scale computational infrastructure, including private and distributed deployments. Through its Biological Information Network, HoX aims to connect geographically and institutionally distributed biological resources into a shared operational environment.
Its current applications include SALIENT, a biosecurity infrastructure for real-time detection, analysis, and coordination of biological threats, and SPLICE, an infrastructure for AI-enabled precision medicine integrating genomic testing, bioinformatics, clinical data, and research environments. HoX also develops browser-based tools for genomic and single-cell data analysis.
Founded by James van Alstine and Phil Hofer, HoX brings together expertise in scientific computing, software engineering, biotechnology, hardware, and health. The company works with research, industrial, and government partners and has announced a pilot contract with Lawrence Livermore National Laboratory to develop next-generation biodefense technology.
HoX describes its broader ambition as bringing biology out of the laboratory and into the world—transforming biological infrastructure from fragmented, predominantly manual systems into an integrated, software-native ecosystem.